A new 3-alkylpyridine alkaloid from the marine sponge Haliclona sp. and its cytotoxic activity |
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| Authors: | Huawei Zhang Steven T Loveridge Karen Tenney Phillip Crews |
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| Institution: | 1. School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P.R. China;2. Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USAhwzhang@zjut.edu.cn;4. Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA |
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| Abstract: | A new alkaloid, 3-dodecyl pyridine containing a terminal cyano group (1), was isolated from the methanol extract of an Indonesia marine sponge Haliclona sp. Its chemical structure was determined by a combination of spectroscopic methods, including 1D and 2D NMR. Bioassay results indicated that compound 1 had moderate cytotoxity against tumour cell lines A549, MCF-7 and Hela with IC50 values of 41.8, 48.4 and 33.2 μM, respectively. |
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| Keywords: | 3-alkylpyridine alkaloid Haliclona sp cytotoxicity |
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