Two new sesquiterpenes from the leaves of Nicotiana tabacum and their anti-tobacco mosaic virus activities |
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| Authors: | Qinpeng Shen Xingmeng Xu Chunbo Liu Wei Zhao Nengjun Xiang Yongkuan Chen |
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| Institution: | 1. Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd, Kunming, P.R. China;2. School of Pharmaceutical Science &3. Yunnan Key Laboratory of Pharmacology for Nature Products, Kunming Medical University, Kunming, P.R. China |
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| Abstract: | Two new sesquiterpenes, nicotianasesterpenes A and B (1 and 2), together with five known sesquiterpenes (3–7) were isolated from the leaves of Nicotiana tabacum. Their structures were determined mainly by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. The anti-tobacco mosaic virus (anti-TMV) activities of compounds 1–7 were evaluated. The results revealed that compound 1 exhibited high anti-TMV activities with inhibition rates of 33.6%. This rate is high than that of positive control. The other compounds also showed potential activities with inhibition rates in the range of 18.8–28.4%, respectively. |
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| Keywords: | Nicotiana tabacum sesquiterpenes anti-tobacco mosaic virus activity |
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