Bacteriostatic activities of N-substituted tris-thioureas bearing amino acid and aniline substituents |
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| Authors: | Wan Sharifatun Handayani Wan Zullkiplee Maya Asyikin Mohd Ariff Hasnain Hussain Wan M Khairul |
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| Institution: | 1. Centre of Pre-University Studies, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia;2. Department of Chemistry, Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia;3. Department of Molecular Biology, Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia;4. School of Fundamental Science, Universiti Malaysia Terengganu, Kuala Terengganu, Terengganu, Malaysia |
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| Abstract: | A series of tri-substituted thiourea derivatives were synthesized by the reaction of 1,3,5-triacetylbenzoyl isothiocyanate with aminoacids and aniline derivatives. All thiourea derivatives were characterized by FT-IR, 1H and 13C NMR spectroscopy. Antibacterial activities against wild-type Escherichia coli American Type Culture Collection 8739 were determined by use of the turbidimetric methodto evaluate the effect of varying amino groups on the synthesized thioureas. Tris-thiourea derivatives bearing ortho-chloroaryl substituents showed excellent antibacterial activity against E. coli with minimal inhibitory concentration (MIC) of 96 ppm. The optimum inhibition was dependent on the type of amines and the position of the halogen in aniline. |
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| Keywords: | Antibacterial activity amino acid tris-thiourea |
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