A new isocoumarin from the aerial parts of Aconitum gymnandrum |
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| Authors: | Jian-Qiang Zhao Yan-Ming Wang Shuo Wang Jun Dang Yan-Ping Shi |
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| Institution: | 1. Key Laboratory of Tibetan Medicine Research of CAS and Key Laboratory for Tibetan Medicine of Qinghai Province, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xinning, P.R. China;2. University of Chinese Academy of Sciences, Beijing, P.R. China;3. Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, P.R. China |
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| Abstract: | A new isocoumarin, along with 10 known compounds, was isolated from the aerial parts of Aconitum gymnandrum. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Among the known compounds, compound 11 was obtained as a natural product for the first time, which was previously reported as a synthetic product. In addition, compounds 1–5, 7 and 9 were tested for their cytotoxicity against four human cancer cell lines. The results showed that compounds 3, 4 and 7 displayed cytotoxicity against lung cancer A549 and gastric cancer MGC80, respectively, whereas 5 and 9 showed selective cytotoxicity against hepatocellular carcinoma HepG2. |
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| Keywords: | Aconitum gymnandrum isocourmain cytotoxic activity |
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