Urease inhibitory profile of extracts and chemical constituents of Pistacia atlantica ssp. cabulica Stocks |
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| Authors: | Ghias Uddin Ismail Muslim Raza Nasruddin |
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| Institution: | 1. Institute of Chemical Sciences, Centre for Phytomedicine and Medicinal Organic Chemistry, University of Peshawar, Peshawar, Pakistanghiasuddin@upesh.edu.pk;3. Institute of Chemical Sciences, Centre for Phytomedicine and Medicinal Organic Chemistry, University of Peshawar, Peshawar, Pakistan |
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| Abstract: | The current study was designed to evaluate the urease inhibitory profile of extract and fractions of Pistacia atlantica ssp. cabulica Stocks followed by bioactivity-guided isolated compounds. The crude extract was found significantly active with urease inhibitor (95.40% at 0.2 mg/mL) with IC50 values of 32.0 ± 0.28 μg/mL. Upon fractionation, ethyl acetate fraction displayed 100% urease inhibition with IC50 values of 19.9 ± 0.51 μg/mL at 0.2 mg/mL. However, n-hexane and chloroform fractions exhibited insignificant urease inhibition. Similarly, the isolated compound, transilitin (1) and dihydro luteolin (2) demonstrated marked urease attenuation with 95 and 98% respectively, at 0.15 mg/mL. Both the isolated compounds showed marked potency with IC50 values of 8.54 ± 0.54 and 9.58 ± 2.22 μg/mL, respectively. In short, both the extract and fractions and isolated compounds showed marked urease inhibition and thus a useful natural source of urease inhibition. |
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| Keywords: | Pistacia atlantica ssp cabulica Stocks chemical constituents urease inhibitory activity |
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