Copper(II)‐Catalyzed Tandem Synthesis of Substituted 3‐Methyleneisoindolin‐1‐ones |
| |
| Authors: | Jie Pan Zhen Xu Runsheng Zeng Jianping Zou |
| |
| Institution: | Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123, China |
| |
| Abstract: | An efficient strategy for the synthesis of a variety of 3‐methyleneisoindolin‐1‐ones has been developed. The reaction proceeded from coupling of 2‐iodobenzamides (or 2‐bromobenzamides) and terminal alkynes via Cu(OAc)2·H2O/2,2′‐biimidazole catalyzed in DMF at 60°C and subsequent additive cyclization produced substituted 3‐methyleneisoindolin‐1‐ones in good to excellent yields. |
| |
| Keywords: | 3‐methyleneisoindolin‐1‐ones Cu(OAc)2· H2O 2 2′ ‐biimidazole additive cyclization |
|
|
