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A Hybrid Ring‐Opening Metathesis Polymerization Catalyst Based on an Engineered Variant of the β‐Barrel Protein FhuA |
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| Authors: | Dr Freddi Philippart Marcus Arlt Steve Gotzen Dr Stefanie‐Joana Tenne Dr Marco Bocola Dr Hsui‐Hui Chen Dr Leilei Zhu Prof Ulrich Schwaneberg Prof Jun Okuda |
| Institution: | 1. Institut für Anorganische Chemie, RWTH Aachen University, Landoltweg 1, 52056 Aachen (Germany);2. Lehrstuhl für Biotechnologie, RWTH Aachen University, Worringer Weg 1, 52074 Aachen (Germany) |
| Abstract: | A β‐barrel protein hybrid catalyst was prepared by covalently anchoring a Grubbs–Hoveyda type olefin metathesis catalyst at a single accessible cysteine amino acid in the barrel interior of a variant of β‐barrel transmembrane protein ferric hydroxamate uptake protein component A (FhuA). Activity of this hybrid catalyst type was demonstrated by ring‐opening metathesis polymerization of a 7‐oxanorbornene derivative in aqueous solution. |
| Keywords: | biocatalysis metalloproteins protein engineering ring‐opening polymerization ruthenium |