Easy One‐Pot Synthesis of 1‐Monosubstituted Aliphatic 1,2,3‐Triazoles from Aliphatic Halides,Sodium Azide and Propiolic Acid by a Click Cycloaddition/Decarboxylation Process |
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| Authors: | Zhongkui Zhang Chunxiang Kuang |
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| Institution: | 1. Department of Chemistry, Tongji University, Shanghai 200092, China;2. Key Laboratory of Yangtze River Water Environment, Ministry of Education, Shanghai 200092, China |
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| Abstract: | 1‐Monosubstituted aliphatic 1,2,3‐triazoles were synthesized by a one‐pot reaction from aliphatic halides (Cl and Br), sodium azide and propiolic acid. The yields ranged from moderate to good. The reaction was easily carried out in DMF with Cs2CO3 at 100°C by copper‐catalyzed click cycloaddition/decarboxylation. |
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| Keywords: | click chemistry copper‐catalyzed decarboxylation 1‐monosubstitued aliphatic 1 2 3‐triazole |
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