Metformin and glitazones: does similarity in biomolecular mechanism originate from tautomerism in these drugs? |
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| Authors: | Sandeep Sundriyal Smriti Khanna Rikta Saha Prasad V Bharatam |
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| Institution: | Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Punjab 160 062, India |
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| Abstract: | This theoretical study attempts to find out similarity between metformin and glitazone class of antidiabetic drugs. It was found that some tautomeric forms of both metformin and thiazolidinedione ring of glitazones have similar molecular electrostatic potential (MESP) surface and may bind to a common complementary surface. Complexation and docking studies were also carried out in order to support this hypothesis. Copyright © 2007 John Wiley & Sons, Ltd. |
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| Keywords: | metformin glitazones tautomerism mechanism of action PPARγ AMPK |
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