Thermosensitive and control release behavior of poly (N‐isopropylacrylamide‐co‐acrylic acid) latex particles |
| |
Authors: | Chia‐Fen Lee Chia‐Cheng Lin Wen‐Yen Chiu |
| |
Institution: | 1. Department of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan, Republic of China;2. Department of Chemical Engineering, National Taiwan University, Taipei, Taiwan, Republic of China;3. Department of Materials Science and Engineering, National Taiwan University, Taipei, Taiwan, Republic of China;4. Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan, Republic of China |
| |
Abstract: | In this work, poly(N‐isopropylacrylamide‐co‐acrylic acid) (poly(NIPAAm‐AA)) copolymer latex particles (microgels) were synthesized by the method of soapless emulsion polymerization. Poly(NIPAAm‐AA) copolymer microgels have the property of being thermosensitive. The concentration of acrylic acid (AA) and crosslinking agent N,N′‐methylenebisacrylamide were important factors to influence the lower critical solution temperature (LCST) of poly(NIPAAm‐AA) microgels. The effects of AA and crosslinking agent on the swelling behavior of poly(NIPAAm‐AA) microgels were also studied. The poly(NIPAAm‐AA) copolymer microgels were then used as a thermosensitive drug carrier to load caffeine. The effects of concentration of AA and crosslinking agent on the control release of caffeine were investigated. How the AA content and crosslinking agent influenced the morphology and LCST of the microgels was discussed in detail. The relationship of morphology, swelling, and control release behavior of these thermosensitive microgels was established. A new scheme was proposed to interpret the control release of the microgels with different morphological structures. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 5734–5741, 2008 |
| |
Keywords: | copolymerization emulsion polymerization latices |
|
|