Synthesis,spectroscopic properties,crystal structure and biological activities of copper(II) 2-methylthionicotinate complexes with furopyridines |
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| Authors: | Peter Segl’a Jozef Miklovič Dušan Mikloš Viera Mrázová Lenka Krupková Daniela Hudecová Zuzana Ondrušová Jozef Švorec Ján Moncol Milan Melník |
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| Institution: | (1) Department of Inorganic Chemistry, Slovak Technical University, Radlinského 9, 812 37 Bratislava, Slovakia;(2) Department of Inorganic Chemistry, Faculty of Natural Sciences, University of St. Cyril and Methodius, 917 01 Trnava, Slovakia;(3) Department of Biochemistry and Microbiology, Slovak Technical University, Radlinského 9, 812 37 Bratislava, Slovakia |
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| Abstract: | The synthesis and characterization of six new 2-methylthionicotinate (2-MeSnic) copper(II) monomeric complexes Cu(2-MeSnic)2L2] (L is furo3,2-c]pyridine—fpy, 2-methylfuro3,2-c]pyridine—Mefpy, 2,3-dimethylfuro3,2-c]pyridine—Me2fpy or benzo4,5]furo3,2-c]pyridine—Bfp), Cu(2-MeSnic)2(fpy)2(H2O)], as well as Cu(2-MeSnic)2(CF3Phfpy)2(H2O)2] (CF3Phfpy is 2-(3-trifluoromethylphenyl)furo3,2-c]pyridine) are reported. The characterizations were based on elemental analysis,
infrared, electronic and EPR spectra. The crystal structure of one of the complexes has been determined. The CuII atoms of Cu(2-MeSnic)2(fpy)2(H2O)] are six-coordinated in a highly distorted tetragonal–bipyramidal arrangement by two nitrogen atoms, one from each fpy,
in trans-positions, by three oxygen atoms of the carboxyl groups of 2-MeSnic ligands (one monodentate, one asymmetrically bidentate),
one axial position being occupied by the oxygen of a water molecule. The antimicrobial effects have been tested on various
strains of bacteria, yeasts and filamentous fungi. A comparison of the IC50 and MIC values has shown a decrease of inhibition activities of tested compounds in the order: Cu(2-MeSnic)2(Bfp)2] > Bfp > Cu(2-MeSnic)2(CF3Phfpy)2(H2O)2] > Cu(2-MeSnic)2(Me2fpy)2] > CF3Phfpy > Cu(2-MeSnic)2(Mefpy)2] > Me2fpy > Cu(2-MeSnic)2(fpy)2(H2O)] > Cu(2-MeSnic)2(H2O)]2 > Mefpy > fpy = 2-MeSnicH = CuSO4.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
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