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A simple, efficient, and selective deuteration via a flow chemistry approach |
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| Authors: | Istvá n M. Má ndity,Ferenc Darvas |
| Affiliation: | a University of Szeged Institute of Pharmaceutical Chemistry, Eötvös u. 6, Szeged H-6720, Hungary b ThalesNano Nanotechnology Inc., Záhony u. 7, Budapest H-1031, Hungary |
| Abstract: | A simple and efficient deuteration methodology has been established for a wide variety of substrates using a continuous flow hydrogenation reactor. The described procedure is many times faster (1 mg min−1) compared to literature methods and the purity of the crude product can be as high as 99%. The deuterium source is D2O, the consumption of which is very low. |
| Keywords: | Deuteration Flow chemistry Heterogenous catalysis Palladium Reduction |
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