Indium triflate-catalyzed vinylation of beta-ketoesters with acetylene gas |
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| Authors: | Nakamura Masaharu Endo Kohei Nakamura Eiichi |
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| Institution: | Department of Chemistry, The University of Tokyo, Hongo, Bunkyo-ku, Japan. |
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| Abstract: | reaction: see text]. An In(OTf)(3)-catalyzed addition of a beta-ketoester to acetylene in the presence of molecular sieves produces a alpha-vinylated ketoester in good to excellent yield. The vinylation reaction proceeds without any loss of elements in starting molecules under solvent-free conditions and allows the use of welding-grade acetylene, providing a practical method for synthetic utilization of acetylene gas. |
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