| 4-硝基喹啉氧化物激发三重态与甲硫氨酸二肽之间的电子转移 |
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| 引用本文： | 徐业平,宋钦华,俞书勤,陈从香,马兴孝,林维真,姚思德.4-硝基喹啉氧化物激发三重态与甲硫氨酸二肽之间的电子转移[J].高等学校化学学报,2000,21(7):1067-1069. |
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| 作者姓名： | 徐业平 宋钦华 俞书勤 陈从香 马兴孝 林维真 姚思德 |
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| 作者单位： | 1. 中国科学技术大学化学物理系, 中国科学院选键化学开放实验室, 合肥 230026;
2. 中国科学院上海原子核研究所辐射化学开放实验室, 上海 201800 |
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| 摘 要： | 4 硝基喹啉氧化物 ( 4ＮＱＯ)在紫外光的作用下 ,发生电子跃迁生成较高量子产额的激发三重态 ,这一性质在光化学研究中可作为光敏剂 ,同时又是一种典型的致癌物 .在水溶液中 ,具有与ＤＮＡ通过电荷转移作用连接到碱基上的性质 ,这一性质可能与其致癌作用有关1～ 4].由于ＤＮＡ具有的遗传功能通过染色体来实现 ,染色体是ＤＮＡ与蛋白质形成的配合物 ,这种蛋白质结合在ＤＮＡ上 ,同ＤＮＡ碱基一样参与化学反应诱导的致癌过程 .因此 ,研究光引发 4ＮＱＯ与氨基酸及相关肽的反应对于了解光诱导 4ＮＱＯ致癌作用的分子机制有重要意义 .Ｓｅｋｉ…
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| 关 键 词： | 硝基喹啉氧化物 含甲硫氨酸的肽 激光闪光光解 电子转移 |
| 收稿时间： | 1999-08-25 |
| 修稿时间： | 1999-08-25 |
Reaction of Electron Transfer from Methionine-containing Dipeptides to Triplet 4-Nitroquinoline 1-Oxide |
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| XU Ye-Ping,SONG Qin-Hua,YU Shu-Qin,CHEN Cong-Xiang,MA Xing-Xiao,LIN Wei-Zhen,YAO Si-De.Reaction of Electron Transfer from Methionine-containing Dipeptides to Triplet 4-Nitroquinoline 1-Oxide[J].Chemical Research In Chinese Universities,2000,21(7):1067-1069. |
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| Authors: | XU Ye-Ping SONG Qin-Hua YU Shu-Qin CHEN Cong-Xiang MA Xing-Xiao LIN Wei-Zhen YAO Si-De |
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| Institution: | 1. Department of Chemical Physics, Open Laboratory of Selected-Bond Chemistry of Chinese Academy of Sciences, University of Science and Technology of China, Hefei 230026, China;
2. Laboratory of Radiation Chemistry, Shanghai Institute of Nuclear Research, Chinese Academy of Sciences, Shanghai 201800, China |
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| Abstract: | Photochemical reactions of 4-nitroquinoline 1-oxide(4NQO) with methionine-containing dipeptides Met-Met, Ala-Met, Met-Lue and Met-Gly have been studies by using 248 nm laser flash photolysis. The formation of α-alkyl radicals was observed, and their rate constants of formation were obtained. The reaction mechanism that the α-alkyl radicals produced via an electron transfer process between triplet 4NQO and methionine-containing dipeptide was proposed. |
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| Keywords: | Nitroquinoline 1-oxide Methionine-containing dipeptides Laser flash photolysis Electron transfer |
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