Crystal Structure and Activity against Acetaminophen-induced Hepatotoxicity of a Potassium Complex with Taurine-5-bromosalicylaldehyde Schiff Bases

A novel potassium complex KC9H9NO4SBr has been synthesized and charac-terized by IR spectra and single-crystal X-ray diffraction method. The crystal belongs to orthor-hombic, space group Pbca with a=0.74040(15), b=0.74960(15), c=4.2620(9) nm, V= 2.3654(8) nm3, Mr = 346.24, Dc = 1.945 g/cm3, Z= 8, F(000) = 1376, μp(MoKa) = 4.005mm-1, GOOF= 1.021, R = 0.0471 and wR = 0.0872. In the crystal, the potassium ion is typically eight-coordinated, surrounded by eight O atoms from six (E)-2-(5-bromo-2-hydroxy-benzyli-deneamino)ethane-sulfonate anions. The neighboring potassium ions are bridged by sulfonate groups into a two-dimensional layer structure, above and below which the 5-bromo-2-hydroxy-benzene rings are protruded. The activity against acetaminophen-indueed hepatotoxieity of this complex was also studied, and found it can protect liver from hepatotoxieity induced by acetaminophen (AAP) to some extent.