Synthesis and biological activity of ethyl 2-(5-methyl-3-arylisoxazole-4-carboxamido)-4-alkylthiazole-5-carboxylate |
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Authors: | Wei Wang Min-Zhen Mao Xiao-Guang Zhang Xiao-Rui Zheng Xiao-Ying Huang |
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Institution: | 1. State Key Laboratory of Fluorine &2. Nitrogen Chemicals, Xi'an Modern Chemistry Research Institute, Xi'an, Shaanxi, P. R. Chinawangwei204@aliyun.com bkning@126.com wlpcxm@qq.com;4. Nitrogen Chemicals, Xi'an Modern Chemistry Research Institute, Xi'an, Shaanxi, P. R. China |
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Abstract: | A series of novel ethyl 2-(5-methyl-3-arylisoxazole-4-carboxamido)-4-alkylthiazole-5-carboxylates I-1-6 were synthesized. The structures of all target compounds were characterized by 1H NMR, 13C NMR, IR, MS and elemental analyses. Their fungicidal and herbicidal activities were evaluated. The results of preliminary bioassays show that the title compounds I-4 possess 20–50% inhibition against most of the tested plants at the dosage of 150 g ai/ha, while the title compounds I-1-5 possess 32–58% inhibition against FusaHum graminearum, Thanatephorus cucumeris, Botrytis cinereapers and Fusarium oxysporum in vitro at the concentration of 100 mg/L. |
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Keywords: | Synthesis Thiazole Isoxazole Herbicidal activity Fungicidal activity |
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