Cytotoxic activity of alkyl benzoate and fatty acids from the red sea sponge Hyrtios erectus |
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| Authors: | Usama W Hawas Lamia T Abou El-Kassem Mohamed S Abdelfattah Mohammed I Y Elmallah Mennat Allah G Eid Marwa M Monier |
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| Institution: | 1. Faculty of Marine Sciences, Marine Chemistry Department, King Abdulaziz University, Jeddah, Saudi Arabia;2. Phytochemistry and Plant Systematic Department, National Research Centre, Cairo, Egyptuhawas@kau.edu.sa;4. Pharmacognosy Department, National Research Centre, Cairo, Egypt;5. Faculty of Science, Marine Natural Products Research Unit, Helwan University, Cairo, Egypt |
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| Abstract: | The chemical investigation of the methylene chloride fraction of marine sponge Hyrtios erectus led to the isolation of the known oxysterol (2) along with a new alkyl benzoate compound identified by spectroscopic methods (NMR and MS) as 4′-methylheptyl benzoate (1), whilst the n-butanol fraction afforded the known indole 3-carbaldehyde and β-carboline derivatives. Moreover, the hexane fraction was analysed by GC–MS for their fatty acids (FAs). A total of 17 FAs with chain lengths between 14 and 25 carbons were identified. Methyl-branched FAs are predominated suggesting the presence of bacterial symbionts in the H. erectus sponge. Furthermore, compounds 1 and 2 displayed significant cytotoxicity against breast adenocarcinoma (MCF-7) with IC50 values of 2.4 and 3.8 μM, respectively, since compound 2 was also shown to have potent cytotoxic effect against hepatocellular carcinoma cells (HepG 2) with IC50 value of 1.3 μM. |
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| Keywords: | Red Sea sponge Hyrtios erectus alkyl benzoate fatty acids cytotoxicity |
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