Convenient synthesis,antimicrobial evaluation and molecular modeling of some novel quinoline derivatives |
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Authors: | Wafaa S Hamama Mona E Ibrahim Aya A Gooda Hanafi H Zoorob |
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Institution: | 1. Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egyptwshamama53@gmail.com wshamama@yahoo.com;3. Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt |
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Abstract: | α, β-Unsaturated carbonyl compounds 2a, 2b, 3, and 4 were synthesized by the Knoevenagel condensation between 2-substituted quionoline-3-carboxaldehyde 1a and/or 1b with active methylene compounds. In addition, the synthesis of azlactone is achieved starting from 1a and N-acetylglycine. Synthesis of pyridine, pyrene, and pyrimidine derivatives 6–8 were accomplished via one-pot multicomponent reaction of 1b with acetyl acetone, malononitrile, and ammonium acetate; acetophenone, malononitrile, and NaOH; or acetyl acetone and urea in acidic medium. The new synthesized compounds showed good antimicrobial activities. The DFT calculations have been used to predict the electronic properties of the studied compounds. |
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Keywords: | α" target="_blank">α β-unsaturated carbonyl compounds" target="_blank">β-unsaturated carbonyl compounds antimicrobial agent gap energy HOMO level LUMO level pyridine pyrimidines quinoline |
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