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Expeditious synthesis of 9-allenylpurines via cesium carbonate catalyzed isomerization of 9-alkynylpurines |
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| Authors: | Mingwu Yu Xiguang Liu Qingsong Jiang Hongguang Du |
| Institution: | 1. School of Chemical and Materials Science, Ludong University, Yantai, P.R. of Chinaymw2007@163.com;3. School of Chemical and Materials Science, Ludong University, Yantai, P.R. of China;4. Faculty of Science, Beijing University of Chemical Technology, Beijing, P.R. of China |
| Abstract: | An expeditious and convenient method to synthesize 9-allenylpurines via cesium carbonate catalyzed isomerization of 9-alkynylpurines has been successfully developed. The reactions proceeded rapidly under the base conditions and formed the desired products in good to excellent yields. The method was suitable with a broad substrate scope and proceeded well even on a multgram-scale. The obtained 9-allenylpurines were successfully applied to prepare various potential bioactive 9-acyclic nucleosides with high regioselectivity promoted by AgNO3. |
| Keywords: | 9-Allenylpurines 9-Alkynylpurines Cesium carbonate Isomerization 9-Acyclic nucleosides |