A new furofuran lignan from Piper terminaliflorum Tseng |
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| Authors: | Tie Liu Qian Liang Xin-Min Zhang Shen-Yang Huang |
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| Affiliation: | 1. Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education, Southwest Forestry University, Kunming, P. R China;2. Department of Medicinal Plant, School of Forestry, Southwest Forestry University, Kunming, P. R China;3. Key Laboratory of Forest Disaster Warning and Control of Yunnan Province, Southwest Forestry University, Kunming, P. R China |
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| Abstract: | ![]()
The chemical investigation of whole plants Piper terminaliflorum Tseng led to the isolation of one new furofuran lignan, 7-methoxyasarinin (1), along with three known amide alkaloids (2–4) as N-3,5-dimethoxy-4-hydroxycinnamoylpyrrole (2), dihydropipercide (3) and 1-[(2E,4E,9E)-10-(3,4-Methylenedioxyphenyl)-2,4,9-undecatrienoyl]pyrrolidine (4). Their structures were elucidated by extensive spectroscopic analyses, including 1D, 2D NMR and HR-ESI-MS, and by comparison with the literature. Compounds (2–4) were isolated from Piper terminaliflorum Tseng for the first time. All isolated compounds (1–4) were evaluated for their cytotoxic activities against five human cancer cell lines (including A-549, SMMC-7721, HL-60, MCF-7 and SW-480). |
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| Keywords: | Piper terminaliflorum Tseng furofuran lignan amide alkaloid cytotoxic activities |
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