Solvent-free synthesis of polyhydroquinoline and 1,8-dioxodecahydroacridine derivatives through the Hantzsch reaction catalyzed by a natural organic acid: A green method |
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| Authors: | Imène Sehout Raouf Boulcina Boudjemaa Boumoud Taous Boumoud |
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| Affiliation: | Laboratoire de synthèse de molécules d’intérêts biologiques, Faculté des Sciences Exactes, Université Frères Mentouri Constantine 1, Constantine, Algeria |
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| Abstract: | Solvent-free and high yielding one-pot synthesis of 1,8-dioxodecahydroacridine and polyhydroquinoline derivatives have been described through Hantzsch condensation of various aldehydes, ammonium acetate with cyclic 1,3-dicarbonyl compounds and ethyl acetoacetate in a very simple, efficient, and environmentally benign method using ascorbic acid as a nontoxic organocatalyst. |
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| Keywords: | 1,8-Dioxodecahydroacridine ascorbic acid Hantzsch reaction polyhydroquinoline solvent-free conditions |
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