Synthesis of pectin-N,N-dimethyl acrylamide hydrogel by gamma radiation and application in drug delivery (in vitro) |
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| Authors: | Md Murshed Bhuyan Hirotaka Okabe Yoshiki Hidaka Nirmal Chandra Dafader Nazia Rahman Kazuhiro Hara |
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| Affiliation: | 1. Research Institute of Environment for Sustainability, Faculty of Engineering, Kyushu University, Motooka, Nishi-ku, Fukuoka, Japanmurshed@athena.ap.kyushu-u.ac.jp;3. Research Institute of Environment for Sustainability, Faculty of Engineering, Kyushu University, Motooka, Nishi-ku, Fukuoka, Japan;4. Nuclear and Radiation Chemistry Division, Institute of Nuclear Science and Technology, Bangladesh Atomic Energy Commission, Dhaka, Bangladesh |
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| Abstract: | The objective of the work is to synthesize pectin-N, N-Dimethylacrylamide (DMAA) hydrogel by gamma radiation without using any initiators and cross-linking agents. Effect of radiation doses on gel fraction and equilibrium swelling as a function of pH were studied, and 5 kGy radiation dose was found to be the optimum dose for hydrogel synthesis. The grafting /crosslinking was investigated by Fourier transform infrared spectroscopy. Thermal properties and surface morphology were studied by differential scanning calorimetry and scanning electron microscopy. To study the drug release kinetics, 5-fluorouracil was loaded into the hydrogel and in vitro release was carried out in simulated gastric and intestinal fluid. The release profile of drug showed that more than 90% of the loaded drugs were released after 4 hours at both gastric fluid and intestinal fluid pH. Drug release data was fitted into zero order, Higuchi and Korsmeyer-Peppas kinetic models. Higuchi model was found to be the best fitted and release exponent ‘n’ value of Korsmeyer-Peppas model indicated the non-Fickian transport. |
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| Keywords: | hydrogel Gamma radiation pectin drug delivery 5-Flourouracil |
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