Synthesis,characterization, DNA binding and cleavage activity of homoleptic zinc(II) β-oxodithioester chelate complexes |
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| Authors: | Manoj Kumar Yadav Akhilendra Kumar Maurya Gunjan Rajput Krishna Kumar Manar Manjula Vinayak Michael G B Drew |
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| Institution: | 1. Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, India;2. Biochemistry &3. Molecular Biology Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, India;4. Department of Chemistry, University of Reading, Reading, UK |
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| Abstract: | New homoleptic zinc(II) complexes, Zn(L)2], where L = methyl-3-hydroxy-(3-pyridyl)-2-propenedithioate L1 1, and methyl-3-hydroxy-(4-pyridyl)-2-propenedithioate L2 2, have been synthesized and characterized by elemental (C, H, and N) analysis, ESI-MS, and (IR, UV–vis, NMR) spectroscopy; the structure of 1 has been deduced by X-ray crystallography. The DNA binding and cleavage activity of the complexes have been studied. The cleavage potential of pBR322 DNA by 1 and 2 has been checked. Complex 1, which contains nitrogen of the pyridine group in the 3-position enhances DNA cleavage potential in the presence of ascorbic acid; however, the complex is protective against DNA cleavage in the presence of DMSO or H2O2. Also, 1 causes cytotoxicity against the MCF-7 breast cancer cell line. The efficient cytotoxic activity and DNA cleavage ability of 1 in the presence of ascorbic acid shows its potential anticancer properties and the need for further investigations of its potential as an anticancer drug. |
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| Keywords: | Anticancer activity DNA Binding DNA Cleavage zinc(II) β-oxodithioester |
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