Synthesis and characterization of oxazine bearing pyridine scaffold as potential antimicrobial agents |
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Authors: | N C Desai N B Bhatt Surbhi B Joshi Darshita V Vaja |
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Institution: | 1. Division of Medicinal Chemistry, Department of Chemistry, UGC NON-SAP &2. DST-FIST Sponsored Department, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar, Indiadnisheeth@rediffmail.com;4. DST-FIST Sponsored Department, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar, India |
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Abstract: | A series of novel compounds 1-((1-(4-(2H-benzoe]1,3]oxazin-3(4H)-yl)phenyl)ethylidene)amino)-6-((benzylidene)amino)-2-oxo-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitriles (7a–o) were synthesized by a sequence of multistep reactions. IR, 1H NMR, 13C NMR, and mass spectral techniques were used to confirm the structures newly synthesized compounds. Antimicrobial activity of the title compounds (7a–o) was studied against strains of bacteria (Staphylococcus aureus and Streptococcus pyogenes, Escherichia coli and Pseudomonas aeruginosa) and fungi (Candida albicans, Aspergillus niger and Aspergillus clavatus) by serial dilution method. Compounds 7f and 7k exhibited significant antimicrobial activity. |
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Keywords: | 2-Oxopyridine antimicrobial activity Mannich reaction Michel addition oxazine |
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