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Isolation and X-ray structure analysis of citreohybridonol from marine-derived Penicillium atrovenetum
Authors:Ferhat Can Özkaya  Weaam Ebrahim  Maximilian Klopotowski  Zhen Liu
Institution:1. Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Düsseldorf, Germany;2. Faculty of Fisheries, ?zmir Katip ?elebi University, ?zmir, Turkey;3. Faculty of Pharmacy, Department of Pharmacognosy, Mansoura University, Mansoura, Egypt;4. Institute of Inorganic and Structural Chemistry, Heinrich-Heine University, Düsseldorf, Germany
Abstract:The anti-neuroinflammatory meroterpenoid citreohybridonol was isolated for the first time from a sponge-derived fungus Penicillium atrovenetum. In this study, in addition to isolation and structure featuring, its unambiguous absolute configuration was determined exclusively by single crystal X-ray diffraction. The C-17-keto tautomer was clearly observed in X-ray analysis. The substance crystallises in the monoclinic space group P21 with a = 10.7496(5) Å, b = 14.3286(7) Å, c = 17.4909(8) Å, β = 103.235(2)°, V = 2622.5(2) Å3, Z = 2, Dcalcd = 1.280 g/cm3. The chirality of the asymmetric carbon atoms was as follows: C3 (S), C5 (R), C6 (S), C8 (S), C9 (R), C10 (R), C13 (R), C14 (R).
Keywords:Citreohybridonol  marine-derived fungi  X-ray  absolute configuration
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