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Three minor new compounds from the aerial parts of Leonurus japonicus |
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| Authors: | Wei-Mao Zhong Zhao-Meng Cui Zhi-Ke Liu Yan Yang Da-Rong Wu Shao-Hua Liu Hui Long Han-Dong Sun Yong-Jun Dang Wei-Lie Xiao |
| Affiliation: | a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;b Key Laboratory of Molecular Medicine, Ministry of Education, and Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai 200032, China;c Chengdu No. 1 Pharmaceutical Group Co., Ltd., Chengdu 610031, China;d University of Chinese Academy of Sciences, Beijing 100049, China |
| Abstract: | Phytochemical investigation of the aerial parts of Leonurus japonicus led to the isolation of one new labdane diterpenoid, leojaponin D (1) and two new ionone derivatives, leojaponones A and B (2 and 3), together with seven known diterpenoids (4-10). Their structures were elucidated by extensive 1D and 2D NMR spectroscopic data and by comparison with data reported in the literature. Selected isolates were evaluated their effects on Jurkat IL2 secretion. |
| Keywords: | Leonurus japonicus Diterpenoid Ionone derivative Jurkat IL2 secretion |
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