Oxygen-Exchange Reaction Between Artificial Lung Device: The Heme Embedded in Polymerized Lipo Liposome as an Artificial Oxygen Carrier |
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| Authors: | Makoto Yuasa Etsuo Hasegawa Hiroyuki Nishide Eishun Tsuchida |
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| Institution: | Department of Polymer Chemistry , Waseda University , Tokyo , 160 , Japan |
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| Abstract: | An oxygen-supplying medium (OSM), which was prepared by embedding a synthetic heme complex in a bilayer of polymerized lipid liposome (polylipid liposome/heme), could bind molecular oxygen reversibly under physiological conditions. The oxygen-exchange reaction of OSM with blood was examined by using a liquid/liquid artificial lung device. For example, deoxy-blood (p s(O2) = 0 torr) was passed countercurrent to oxy-OSM (p s(O2) = 154 torr) through hollow fibers of the device to provide oxy-blood (p b(O2) = 57 torr). The OSM was physicochemically and mechanically stable under strong shear stress during the passage through the hollow fibers and acted as the oxygen mediator to blood. |
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| Keywords: | Pervaporation phenol membrane separation polyurethane |
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