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Stereochemical determination of tetrahydropyran-substituted xanthones from fungus Chaetomium murorum
Authors:Meng-Hua Wang  Li Li  Tao Jiang  Xue-Wei Wang  Bin-Da Sun  Bo Song  Qiu-Bo Zhang  Hong-Mei Jia  Gang Ding  Zhong-Mei Zou
Abstract:Chaetoxanthone D (1), a new tetrahydropyran-substituted xanthone originated from polyketide pathway, together with the four known natural products chaetoxanthone C (2), alternariol methyl ether (3), alternariol (4) and 2,5-dimethyl-7-hydroxychromone (5) was isolated from a strain of Chaetomium murorum. The structures of these compounds were elucidated based on extensive spectroscopic analyses. The absolute configurations of 1 and 2 were determined by using quantum chemical electronic circular dichroism (ECD) calculations.
Keywords:Chaetomium murorum  Xanthone  Chaetoxanthone D  Tetrahydropyran  Absolute configuration  ECD  
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