Reduced expression of TAC1, PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain |
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| Authors: | Julia Lindberg Peter Saetre Seiji Nishino Emmanuel Mignot Elena Jazin |
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| Affiliation: | 1.Evolutionary Biology Centre, Department of Evolution, Genomics and Systematics,Uppsala University,Uppsala,Sweden;2.Evolutionary Biology Centre, Department of Physiology and Developmental biology,Uppsala University,Uppsala,Sweden;3.Sleep Disorders Research Centre, Department of Psychiatry and Behavioral Sciences,Stanford University School of medicine,Stanford,USA |
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| Abstract: | Background Narcolepsy causes dramatic behavioral alterations in both humans and dogs, with excessive sleepiness and cataplexy triggered by emotional stimuli. Deficiencies in the hypocretin system are well established as the origin of the condition; both from studies in humans who lack the hypocretin ligand (HCRT) and in dogs with a mutation in hypocretin receptor 2 (HCRTR2). However, little is known about molecular alterations downstream of the hypocretin signals. |
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