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A glucose sensor via stable immobilization of the GOx enzyme on an organic transistor using a polymer brush |
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| Authors: | M Elizabeth Welch Thomas Doublet Christophe Bernard George G Malliaras Christopher K Ober |
| Institution: | 1. Department of Materials Science & Engineering, Cornell University, Bard Hall, Ithaca, New York, 14853
Department of Chemistry and Chemical Biology, Cornell University, Bard Hall, Ithaca, New York, 14853 M. Elizabeth Welch and Thomas Doublet contributed equally to this work.;2. Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, 880 route de Mimet, 13541 Gardanne, France Aix Marseille Université, INS UMR_S 1106, 13005 Marseille, France M. Elizabeth Welch and Thomas Doublet contributed equally to this work.;3. Aix Marseille Université, INS UMR_S 1106, 13005 Marseille, France Inserm, UMR_S 1106, 13005 Marseille, France;4. Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, 880 route de Mimet, 13541 Gardanne, France |
| Abstract: | Recently, there has been significant research in the area of organic electrochemical transistors (OECTs) because of their superior aptitude of chemical and biological sensing. Here it is shown for the first time the incorporation of polymer brushes to a transistor. Polymer brushes were chosen for their biocompatible properties and their ability to covalently tether enzymes and other biomolecules to different surfaces. OECTs were fabricated from the conducting polymer poly(3,4-ethylenedioxythiophene) doped with poly(styrene sulfonate), PEDOT:PSS, and polymerized from the surface a mixed polymer brush of poly(glycidyl methacrylate) and poly(2-hydroxyethyl methacrylate). The brushes were functionalized with glucose oxidase and measured in terms of electrical performance and long-term stability. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015 , 53, 372–377 |
| Keywords: | conjugated polymers enzymes glucose oxidase organic electrochemical transistor polymer brushes sensors stability |