| 一氧化氮荧光分子探针 |
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| 引用本文： | 张灯青,赵圣印,刘海雄.一氧化氮荧光分子探针[J].化学进展,2008,20(9):1396-1405. |
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| 作者姓名： | 张灯青 赵圣印 刘海雄 |
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| 作者单位： | 东华大学化学化工与生物工程学院,上海,201620 |
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| 摘 要： | 一氧化氮（NO）在生物体中扮演重要的角色，对其选择性识别引起了人们极大的兴趣。本文综述了两类NO荧光分子探针的研究进展，即含金属离子的NO荧光分子探针：如Co(Ⅱ)、Fe(Ⅱ)、 Ru(Ⅱ)、Rh(Ⅱ)和Cu(Ⅱ)配合物作为荧光打开的NO分子探针；邻苯二胺类荧光分子探针：如2,3-二氨基萘（DAN）、二氨基荧光素衍生物（DAFs）、二氨基罗丹明衍生物（DARs）、硼二吡咯甲基衍生物（BODIPY）和三碳菁衍生物（DAC）等。
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| 关 键 词： | 一氧化氮 荧光检测 含金属离子的荧光探针 芳香二胺 |
| 收稿时间： | 2007-10-19 |
| 修稿时间： | 2007-12-18 |
Fluorescent Probes for Sensing Nitric Oxide |
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| Zhang Dengqing,Zhao Shengyin,Liu Haixiong.Fluorescent Probes for Sensing Nitric Oxide[J].Progress in Chemistry,2008,20(9):1396-1405. |
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| Authors: | Zhang Dengqing Zhao Shengyin Liu Haixiong |
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| Institution: | (College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620, China) |
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| Abstract: | Nitric oxide (NO), a reactive free radical, regulates a variety of biological processes. Therefore its accurate detection and quantification are critical to understanding health and disease. In this review, two types of fluoresent probes for NO are mainly desccibed, namely, metal-based sensors, which utilizing NO binding to the metal center, such as Co(Ⅱ), Fe(Ⅱ), Ru(Ⅱ), Rh(Ⅱ) and Cu(Ⅱ) complexes as turn-on fluoresent NO sensors; Organic molecule-based sensors, which are mainly diamine fluoresent indicators for NO, such as DAN, DAFs, DARs, BODIPY and DACs. |
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| Keywords: | nitric oxide fluorescent detection metal-based fluorescent probes aromatic diamino compounds |
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