|
|||||
|
|
Pd(II)-catalyzed coupling-cyclization reaction of o-ethylnylphenylphosphonamides monoesters with allyl halide |
|
| Authors: | Wei Tang Yi-Xiang Ding |
| Affiliation: | a Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China b College of Life and Environment Sciences, Shanghai Normal University, Shanghai 200234, China |
| Abstract: | 4-Allyl-phosphaisoquinolin-1-ones were synthesized by palladium-catalyzed coupling-cyclization of o-ethynylphenylphosphonamide monoethyl esters with allyl halides with high regioselectivity and good yields. The synthesized 4-allyl-phosphaisoquinolin-1-ones show bioactivity as inhibitor of MCH-1R. |
| Keywords: | 4-Allylic phosphaisoquinolin-1-ones Pd(II)-catalyzed Cyclized coupling reaction Allyl halide Heterocycle MCH-1R |
| 本文献已被 ScienceDirect 等数据库收录！ | |