Synthesis of 2,3-unsaturated glycosides via metal-free Ferrier reaction |
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| Authors: | Kavita De,Daniè le Bonnet-Delpon |
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| Affiliation: | Laboratoire BioCIS-CNRS, Faculté de Pharmacie, Univ Paris Sud, rue JB Clément, F-92296 Chatenay-Malabry, France |
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| Abstract: | ![]()
Hexafluoroisopropanol (HFIP) is explored as an effective medium for the synthesis of 2,3-unsaturated glycosides through allylic rearrangement of 3,4,6-tri-O-acetyl glucal. This metal-free, exclusively solvent-promoted Ferrier glycosylation, affords products in good to excellent yields and with good α-selectivity. |
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| Keywords: | Fluorine Hexafluoropropan-2-ol Sugar Glycals |
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