Furo[3,2-b]pyridine: a convenient unit for the synthesis of polyheterocycles |
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| Authors: | Anthony Chartoire |
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| Institution: | SRSMC, Nancy-Université, CNRS, B.P. 239, Boulevard des Aiguillettes, F-54506 Vandoeuvre-lès-Nancy, France |
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| Abstract: | An efficient and rapid synthesis of furo3,2-b]pyridine 1 is described using a one-pot Sonogashira coupling/heteroannulation sequence. Regioselective lithiation of this synthon was performed leading to various 2-substituted furo3,2-b]pyridines. Some of them were used as substrates for short functional synthesis of polyheterocycles. |
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| Keywords: | Furo[3 2-b]pyridine Tandem Sonogashira coupling/heteroannulation Pd-catalyzed cross-coupling Polyheterocycles |
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