Synthetic studies on borrelidin: enantioselective synthesis of the C1-C12 fragment |
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| Authors: | Vong Binh G Abraham Sunny Xiang Alan X Theodorakis Emmanuel A |
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| Institution: | Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, USA. |
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| Abstract: | structure: see text] An efficient, enantioselective synthesis of the C1-C12 fragment 2 of borrelidin is presented. Construction of the "skipped" polymethylene chain of 2 was accomplished by iteration of Myers' alkylation, while formation of the C3 stereocenter was achieved by Roush's asymmetric allylboration methodology. |
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