Electrochemical behavior and in-vitro antimicrobial screening of some thienylazoaryls dyes |
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Authors: | Joseph Tsemeugne Emmanuel Sopbué Fondjo Jean-de-Dieu Tamokou Ignas Tonle Irene Chinda Kengne Arnaud Djintchui Ngongang Stephen Tamekou Lacmata Taoufik Rohand Jules Roger Kuiate Beibam Luc Sondengam |
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Institution: | 1.Laboratory of Applied Synthetic Organic Chemistry, Department of Chemistry, Faculty of Science,University of Dschang,Dschang,Republic of Cameroon;2.Department of Organic Chemistry,University of Yaounde I,Yaounde,Republic of Cameroon;3.Laboratory of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science,University of Dschang,Dschang,Republic of Cameroon;4.Laboratory of Analytical and Molecular Chemistry, Faculty Polydisciplinaire of Safi,University Cadi Ayyad Marrakech,Safi,Morocco |
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Abstract: | BackgroundA series of recently reported phenolic azo dyes 7a–e were prepared by coupling the thienyl diazonium sulfate of 3-Amino-4H-benzof]thieno3,4-c](2H)chromen-4-one with selected diversely substituted phenolic and naphtholic derivatives. These compounds were evaluated for their antibacterial and antifungal activities. Furthermore their voltammetric behavior was compared at a glassy carbon electrode.ResultsThe voltammetric behavior of the five recently reported azo dyes has been compared at a glassy carbon electrode. It is shown that the azo dyes 7a–e with a hydroxyl group in the ortho position with respect to the azo bridge give rise to well defined, irreversible peaks for the oxidation and reduction process within a pH range of 2–7. The mechanisms of electrochemical oxidation of compound 7a–c and 7e are proposed. For the hydroxyl-substituted dyes, re-oxidation peaks were obtained in the subsequent scan. The antimicrobial activities of the reported compounds 7a–e along with the entire precursors 1–4 and 6a–e were performed against selected bacterial and fungal species and their activities compared to those of nystatin, griseofulvin and ciprofloxacin used as reference drugs.ConclusionsThe present study showed significant antimicrobial activity of compounds 6d, 7a and 7c,e against the tested microorganisms; this result confirms the antimicrobial potency of azo compounds and some of their precursors. |
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