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Click chemistry and biocatalysis for the preparation of pancratistatin analogs |
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| Authors: | Victoria de la SoveraAna Bellomo David Gonzalez |
| Affiliation: | Departamento de Química Orgánica, Facultad de Química, UdelaR, CC 1157, Montevideo, Uruguay |
| Abstract: | Tricyclic compounds that are advanced precursors for the synthesis of analogs of the antitumoral alkaloid pancratistatin were prepared by a short sequence that involved enzymatic dihydroxylation, epoxidation, and intramolecular Huisgen cycloaddition. |
| Keywords: | Pancratistatin analogs Chemoenzymatic synthesis Click chemistry Huisgen cycloaddition |
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