New alkaloids from Phoebe grandis (Nees) Merr |
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Authors: | Awang Khalijah Mukhtar Mat Ropi Hadi A Hamid A Litaudon Marc Latip Jalifah Abdullah Noor Rain |
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Institution: | Chemistry Department, University Malaya, 50603 Kuala Lumpur, Malaysia. khalijah@um.edu.my |
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Abstract: | The alkaloidal extract of the leaves of Phoebe grandis (nees) merr. have provided two new minor alkaloids; phoebegrandine D (1), a proaporphine-tryptamine dimer, and phoebegrandine E (2), an indoloquinolizidine. This is the first report on the occurrence of an indoloquinolizidine in the Phoebe species. The crude extract also exhibited antiplasmodial activity (IC50<8 microg mL-1). The structures of the novel compounds were elucidated by spectroscopic methods, notably 2D NMR and HRMS. |
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