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Adjuvant Effects of Dual Co-stimulatory Molecules on Cellular Responses to HIV Multiple-epitope DNA Vaccination |
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| Authors: | SHEN Zhen-wei JIN Hong-tao LI Chang CONG Yan-zhao NAN Wen-long BAI Liang JIN Ning-yi College of Animal Science Veterinary Medicine Jilin University Changchun P R China Genetic Engineering Laboratory Academy of Military Medical Sciences |
| Institution: | [1]College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, P R. China [2]Genetic Engineering Laboratory, Academy of Military Medical Sciences, Changchun 130062, P. R. China |
| Abstract: | Designing adjuvants that can induce strong cytotoxic T cell responses is largely required for preparing DNA vaccines. In this study we explored dual costimulatory molecules 4-1BBL and OX40L as adjuvants to improve the efficiency of the HIV multiple-epitope DNA vaccine. When explored in the human dendritic cell-T cell based coculture system,dual costimulatory molecules significantly enhanced the anti-HIV T cell response of the HIV mul-tiple-epitope DNA vaccine,as detected by intracellular cytokine staining t... |
| Keywords: | HIV DNA vaccine Co-stimulatory molecules 4-1BBL OX40L Dendritic cells |
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