Activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of monoamine oxidase inhibitors |
| |
| Authors: | Krysiak Joanna M Kreuzer Johannes Macheroux Peter Hermetter Albin Sieber Stephan A Breinbauer Rolf |
| |
| Institution: | Institute of Organic Chemistry, Graz University of Technology, Austria. |
| |
| Abstract: | High profile: new activity-based protein profiling (ABPP) probes have been designed that target exclusively monoamine oxidases A and B within living cells (see picture; FAD=flavin adenine dinucleotide, FMN=flavin monodinucleotide). With these probes it could be shown that the MAO inhibitor deprenyl, which is in clinical use against Parkinson's disease, shows unique protein specificity despite its covalent mechanism of action. |
| |
| Keywords: | activity‐based probes deprenyl flavin cofactor monoamine oxidases proteomics |
| 本文献已被 PubMed 等数据库收录！ |
