Oxidative Difunctionalization of Alkenyl MIDA Boronates: A Versatile Platform for Halogenated and Trifluoromethylated α‐Boryl Ketones |
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| Authors: | Wen‐Xin Lv Yao‐Fu Zeng Dr Qingjiang Li Dr Yunyun Chen Dong‐Hang Tan Ling Yang ProfDr Honggen Wang |
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| Institution: | 1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China;2. Stake Key Laboratory of Natural and Biomimetic Drugs, Peking University, China |
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| Abstract: | The synthesis of halogenated and trifluoromethylated α‐boryl ketones via a one‐pot oxidative difunctionalization of alkenyl MIDA boronates is reported. These novel densely functionalized organoborons bearing synthetically and functionally valuable carbonyl, halogen/CF3 and boronate moieties within the same molecule are synthetically challenging for the chemist, but have great synthetic potential, as demonstrated by their applications in a straightforward synthesis of borylated furans. The generality of this reaction was extensively investigated. This reaction is attractive since the starting materials, alkenyl MIDA boronates, are easily accessible. |
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| Keywords: | alkenes halogenation organoboron oxidation trifluoromethylation |
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