Construction of Chiral Tri‐ and Tetra‐Arylmethanes Bearing Quaternary Carbon Centers: Copper‐Catalyzed Enantioselective Propargylation of Indoles with Propargylic Esters |
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| Authors: | Kouhei Tsuchida Yasushi Senda Dr. Kazunari Nakajima Prof. Dr. Yoshiaki Nishibayashi |
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| Affiliation: | Department of Systems Innovation, School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan |
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| Abstract: | Copper‐catalyzed enantioselective propargylation of indoles with propargylic esters and sequential Huisgen cycloaddition with azides lead to the construction of chiral triarylmethanes, bearing a quaternary carbon center, with high to excellent enantioselectivities. The result described herein can be used in the enantioselective preparation of a tetraarylmethane. |
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| Keywords: | alkynes copper cycloadditions enantioselectivity synthetic methods |
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