The rhodium complex of a tris(bipyridine) ligand—Its electrochemical behaviour and function as mediator for the regeneration of NADH from NAD+ |
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Authors: | Smaragda Grammenudi Marlene Franke Fritz Vögtle Eberhard Steckhan |
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Institution: | (1) Institut für Organische Chemie und Biochemie der Universität Bonn, Gerhard-Domagk-Strasse 1, D-5300 Bonn 1, West Germany |
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Abstract: | The tris-bipyridine ligand3a and its stoichiometric Rh3+ complex have been prepared. Cyclovoltammograms of the complex at pH 7.4 using a glassy carbon disk electrode reveal a strong reduction peak at –620 mV and two weak reduction peaks at more negative voltage. The reduction potential of the new complex is shifted by 300 mV to more positive values as compared to Rh(bipy)3]3+. There is no reversible reoxidation peak of the Rh(I) complex formed due to the decomplexation of one of the three bipyridine units in the course of the transition Rh(III)Rh(I). The Rh(III) complex of3a was also studied with respect to its function as a possible redox mediator for the electrochemical regeneration of NADH from NAD+. The preparative electrolysis of the Rh3+ complex of3a in the presence of NAD+ yields a selective formation of NADH, whereas NAD dimers were not detected. On the other hand, a significant acceleration of this reaction compared to Rh(bipy)3]3+ was not observed. |
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Keywords: | Bipyridine bipyridine ligand complexation complex chemistry complex formation cyclovoltammetry electrochemical mediator electrochemical reduction electrochemistry NAD+ NADH Rh3+ Rh+ Rh complex |
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