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Pestaloamides A and B,two spiro-heterocyclic alkaloid epimers from the plant endophytic fungus Pestalotiopsis sp. HS30 |
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| Authors: | Su Xiao-Zheng Zhu Yi-Ying Tang Jian-Wei Hu Kun Li Xiao-Nian Sun Han-Dong Li Yan Puno Pema-Tenzin |
| Institution: | 1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, 650201, China ;2.University of Chinese Academy of Sciences, Beijing, 100049, China ; |
| Abstract: | Pestaloamides A and B(1 and 2), two novel alkaloids featuring an unprecedented spiroimidazothiazoledione-alkylidenecyclopentenone] scaffold, were obtained from the cultures of an endophytic fungus Pestalotiopsis sp. HS30 which inhabited the stems of Isodon xerophilus. Their planar structures and absolute configurations were fully determined by extensive spectroscopic analysis and X-ray crystallography. In addition, both compounds 1 and 2 showed the latent tumor immunotherapy activity through markedly promoting the cell surface engagement of NKG2 D ligands involving MICA/B and ULBP1 in HCT116 cells. |
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