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| Palladium-catalyzed ortho-C–H silylation of biaryl aldehydes using a transient directing group | |
| 摘 要： | A strategy for Pd-catalyzed ortho-C–H silylation of biaryl aldehydes enabled by a transient auxiliary is presented. This protocol provides a broad range of ortho-silylated biaryl aldehydes in good yields. The silyl moiety can be further functionalized under mild conditions, rendering the silylated products useful building blocks. Notably, this protocol also offers an opportunity to establish a platform for expeditious synthesis of structurally diverse axially chiral biaryl aldehydes via sequential atroposelective interannular C–H functionalization/intraanular C–H silylation. |
Palladium-catalyzed ortho-C-H silylation of biaryl aldehydes using a transient directing group |
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| Authors: | Wu Yong-Jie Yao Qi-Jun Chen Hao-Ming Liao Gang Shi Bing-Feng |
| Institution: | 1.Department of Chemistry, Zhejiang University, Hangzhou, 310027, China ;2.School of Chemical & Environmental Engineering, Wuyi University, Jiangmen, 529020, China ; |
| Abstract: | Science China Chemistry - A strategy for Pd-catalyzed ortho-C-H silylation of biaryl aldehydes enabled by a transient auxiliary is presented. This protocol provides a broad range of ortho-silylated... |
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