Synthesis of New Estrone Derivatives Using Excess Oxalyl Chloride |
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| Authors: | L Nahar S D Sarker P K Li A B Turner |
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| Institution: | (1) Japp Laboratory, Department of Chemistry, University of Aberdeen, Meston Walk, Old Aberdeen, Aberdeen, AB24 3UE, Scotland, UK;(2) Phytopharmaceutical Research Laboratory, School of Pharmacy, The Robert Gordon University, Schoolhill, Aberdeen, AB10 1FR, Scotland, UK;(3) Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Ohio State University, 500 W 12th Ave, Columbus, OH 43210, USA |
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| Abstract: | The synthesis and structure elucidation of three new estrone derivatives chloro-oxo-acetic acid (estra-1,3,5(10)-trien-17-on-3-yl methyl) ester (2), oxalic acid mono (estra-1,3,5(10)-trien-17-on-3-yl methyl) ester (3), and ethyl (3-methoxyestra-1,3,5(10)-trien)-17 -yl oxalate (5) have been described. |
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| Keywords: | steroids estrone esterification oxalyl chloride NMR |
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