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Aggregation of polyene antibiotics as revealed by absorption spectroscopy |
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| Authors: | Zameer Shervani |
| Affiliation: | Liposome Research Centre, Department of Biochemistry, University of Delhi South Campus, New Delhi-110021, India |
| Abstract: | Methanolic solutions of the heptaene macrolide antibiotics, namely amphotericin B and hamycin, are molecular dispersions. These polyenes were found to be self-aggregated in neutral aqueous solution. The aggregates of hamycin dissociate in acidic or basic aqueous solutions. The smaller chain aliphatic alcohols have a higher solvating power for hamycin. |
| Keywords: | Amphotericin B hamycin polyene antibiotics self-aggregation solvent effect. |
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