New acridine derivatives bearing immobilized azacrown or azathiacrown ligand as fluorescent chemosensors for Hg and Cd期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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New acridine derivatives bearing immobilized azacrown or azathiacrown ligand as fluorescent chemosensors for Hg and Cd

Authors:	Han Na Lee Ha Na Kim KMK Swamy Min Sun Park Hyunsook Lee Sungsu Park

Institution:	^a Division of Nano Science and Department of Chemistry, Ewha Womans University, Seoul 120-750, Republic of Korea ^b Department of Pharmaceutical Chemistry, V.L.College of Pharmacy, Raichur 584 103, India ^c Department of Biological Sciences, Research Center for Functional Cellulomics, College of Natural Sciences, Seoul National University, Seoul 151-742, Republic of Korea ^d Department of Chemistry, Inha University, Incheon 402-751, Republic of Korea

Abstract:	Two new acridine derivatives bearing azacrown or azathiacrown ligand were synthesized as fluorescent chemosensors for Hg²⁺ and Cd²⁺ in aqueous solution. Compounds 1 and 2 displayed selective CHEF (chelation enhanced fluorescence) effects with Hg²⁺ or Cd²⁺ among the metal ions examined. The practical use of these probes was demonstrated by their applications to the detection of Hg²⁺ and Cd²⁺ ions in mammalian cells.

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