| α-十四烷基-DOTA及其钆(Ⅲ)螯合物的合成与表征(英) |
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| 引用本文： | 冯志明,李 峰,雷春华,陈 蓉,李晓如.α-十四烷基-DOTA及其钆(Ⅲ)螯合物的合成与表征(英)[J].无机化学学报,2004,20(4):435-438. |
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| 作者姓名： | 冯志明 李 峰 雷春华 陈 蓉 李晓如 |
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| 作者单位： | 1. 湖南师范大学化学化工学院,长沙,400081
2. 中南大学化学化工学院,长沙,410083 |
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| 基金项目： | 湖南省科技厅资助项目(No.OOSSY1013鄄51)。 |
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| 摘 要： | Synthesis and characterization of the ligand, 10-(α-tetradecylcarboxymethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid, H4L] and its Gd(Ⅲ) chelate are described. Protonation constants for H4L(lgKiH = 10.62, 9.50, 4.74, 4.12) and the stability constant for GdL-(lgKGdL-= 24.60) were determined by potentiometric titrations. The results obtained show that the basicity of the ligand is not significantly altered and the ligand still maintains the strong chelating properties of the parent DOTA after introduction of a linear chain tetradecyl group at the acetic side chain of DOTA.
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| 关 键 词： | 钆(Ⅲ)螯合物 DOTA衍生物 稳定性 |
Synthesis and Characterization of α-Tetradecyl-DOTA and Its Gd(Ⅲ) Chelate |
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| FENG Zhi-Ming,LI Feng,LEI Chun-Hu,CHEN Rong and LI Xiao-Ru.Synthesis and Characterization of α-Tetradecyl-DOTA and Its Gd(Ⅲ) Chelate[J].Chinese Journal of Inorganic Chemistry,2004,20(4):435-438. |
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| Authors: | FENG Zhi-Ming LI Feng LEI Chun-Hu CHEN Rong and LI Xiao-Ru |
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| Institution: | College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081,College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081,College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081,College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081 and College of Chemistry and Chemical Engineering, Centralsouth University, Changsha 410083 |
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| Abstract: | Synthesis and characterization of the ligand, 10-(α-tetradecylcarboxymethyl)-1,4,7,10-tetraazacyclododecane1,4,7-triacetic acid, H4L] and its Gd(Ⅲ) chelate are described. Protonation constants for H4L(lgKiH = 10.62, 9.50,4.74, 4.12) and the stability constant for GdL- (lgKG dL- = 24.60) were determined by potentiometric titrations. The results obtained show that the basicity of the ligand is not significantly altered and the ligand still maintains the strong chelating properties of the parent DOTA after introduction of a linear chain tetradecyl group at the acetic side chain of DOTA. |
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| Keywords: | Gd(Ⅲ)chelate DOTA derivative stability |
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