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| Design, Synthesis and Biological Evaluation of Non-azole Inhibitors of Lanosterol 14α-Demethylase of Fungi | |
| 引用本文： | Bin YAO,You Jun ZHOU,Jü ZHU,Jia Guo Lü,Yao Wu LI,Jun CHENG,Qing Feng JIANG,Can Hui ZHENG School of Pharmacy,Second Military Medicial University,Shanghai .Design, Synthesis and Biological Evaluation of Non-azole Inhibitors of Lanosterol 14α-Demethylase of Fungi[J].中国化学快报,2006,17(9):1189-1192. |
| 作者姓名： | Bin YAO You Jun ZHOU Jü ZHU Jia Guo Lü Yao Wu LI Jun CHENG Qing Feng JIANG Can Hui ZHENG School of Pharmacy Second Military Medicial University Shanghai |
| 作者单位： | Bin YAO，You Jun ZHOU，Jü ZHU，Jia Guo Lü，Yao Wu LI，Jun CHENG，Qing Feng JIANG，Can Hui ZHENG School of Pharmacy，Second Military Medicial University，Shanghai 200433 |
| 基金项目： | Acknowledgments The work was supported by the National Natural Science Foundation of China （No. 30572257） |
| 摘 要： | Lanosterol 14α-demethylase (CYP51) is one of the key enzymes of sterol biosynthesis in fungi, and is also a prime target for development of antifungal drugs. Azoles such as ketoconazole, fluconazole and itraconazole are only a class of inhibitors of CYP5… |
| 关 键 词： | Antifungal 2-aminotetralins lanosterol 14α-demethylase inhibitor. |
| 收稿时间： | 2006-03-27 |
| 本文献已被 CNKI 等数据库收录！ | |